Perhaps jv16 PowerTools 2005 is not compatible with Vista? I see they now have a version for 2006 available for now, and on this page, it asks about Vista compatibility:
Windows Optimization and Registry Cleaner FAQ | Macecraft Software
Question:
Are your products compatible with Vista?
Answer:
All of our products are compatible with Windows Vista.
But in order for the program to work properly, it must have full administrator rights. You can run a program with administrator rights in Vista simply by right-clicking the software and selecting Run as administrator.